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In 1967 Dr. Smith established a graduate program in toxicology at UC's College of Medicine, where he was a professor of environmental health and biological chemistry until his retirement in 1983.

Before establishing the program, Dr. Smith was at the Christ Hospital Institute of Medical Research from 1944 to 1966 as a research associate and then acting director for his last three years at the hospital. He also did a two-year research associateship at the Merck Institute in New Jersey.

Over his career, Dr. Smith conducted research on hypertension, drug metabolism, cancer and other diseases. He authored 89 scientific papers and lectured throughout the United States and Europe.

Dr. Smith was chairman of the 1972 Gordon conference on drug metabolism. In 1980 he spent a year at the Princess Margaret Cancer Hospital in Toronto.

He was born in Lima, Ohio, in 1914. He graduated cum laude from DePauw University in 1936, and earned a master's degree in 1937 from the University of Cincinnati and a doctor of philosophy in 1940, both in biological chemistry.

He was a member of the Society of Toxicology, and was founder and chairman of the mechanism section graduate student award, later named the Carl C. Smith Graduate Student award.

Dr. Smith was a 50-year member of the American Chemical Society, a charter member of the American Metabolism Newsletter, a charter member of the International Society for the Study of Xenobiotics and was awarded a fellowship in the Academy of Toxicological Science.

He had a lifelong interest in music, playing both violin and French horn. He founded a symphony orchestra in Rahway, N.J., and played violin in the Cincinnati Civic Orchestra.

He also was a member of Corryville Community Council and an elder in Mount Auburn Presbyterian Church.

Also surviving are three daughters, Marcia Chiampas of New York City, Pamella Binkley of Cincinnati and Vernetta Fluegeman of Muncie, Ind.; and three grandchildren.

The service will be 1 p.m. today in Mount Auburn Presbyterian Church, 103 William Howard Taft Road. Burial will be in Spring Grove Cemetery in Winton Place.

Published in The Cincinnati Inquirer November 5, 1997, Pg 9. An obituary was in Post & Mail November 11, 1997, Pg 2.

NOTE: Parents were Frank O. & Eva K. (Urich) Smith. Sister Frances K. Smith 1917-1999. Wife Thelma died in 2015.">

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